On semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound), up to 25β40% of the weight you lose can be lean muscle. Enough protein is your best defense. Find your daily target, then fill your day.
Tap + to add servings. The gauge fills toward your goal. Protein values are per-serving, derived from USDA FoodData Central (per-100 g measured values).
GLP-1 receptor agonists like semaglutide and tirzepatide work by slowing gastric emptying and blunting appetite, so you eat less almost effortlessly. The catch: when weight comes off fast and total intake drops, a meaningful share of the loss is lean tissue rather than fat. Trials and reviews of GLP-1βdriven weight loss report that roughly 25β40% of the weight lost can be lean body mass unless protein intake and resistance training are deliberately protected. Muscle is metabolically expensive tissue β losing it lowers your resting energy needs and makes long-term maintenance harder.
Two levers protect muscle during a calorie deficit: enough protein and resistance training. This page is about the first. The consensus for the active weight-loss phase is roughly 1.2β1.6 grams of protein per kilogram of body weight per day, with an absolute floor near 80β120 grams per day so that very light or very heavy people still land in a sensible range.
| Source | Recommendation | Reference |
|---|---|---|
| Mozaffarian et al., 2025 β joint ACLM / ASN / OMA / TOS nutrition guidance for obesity medications | 1.2β1.6 g/kg/day during active weight loss; absolute intake ~80β120 g/day; routine intake above 2.0 g/kg not generally recommended | Obesity, 2025. doi:10.1002/oby.24336 |
| AACE 2025 Consensus Statement on nutrition & muscle in obesity treatment | At least β₯1.2 g/kg/day protein to preserve lean mass during pharmacologic weight loss | AACE Consensus, 2025 |
| JISSN 2025 position on protein during GLP-1 therapy | 1.2β2.0 g/kg/day, calculated on adjusted body weight for higher-BMI individuals | J Int Soc Sports Nutr, 2025. doi:10.1080/15502783.2025.2550139 |
This calculator uses 1.2β1.6 g/kg as its default band, switches to adjusted body weight at BMI β₯ 30 (Devine ideal weight + 40% of the excess), applies an 80 g/day floor, and caps its coefficient at 2.0 g/kg β directly reflecting the ranges above.